Figure 12

Quantitation of tau burden using AT8 for the hippocampus of 3xTg mice. The tau burden was analyzed semiquantitatively on a scale of 0 to 4. Representative brain sections of both (A) vehicle control and (B) pBri-treated Tg mice immunostained with AT8 from the hippocampus. (C) Bar graph of tau semiquantitative analysis for the hippocampus of Tg control and pBri-vaccinated mice. On average there was a 55% reduction in the areas occupied by AT8 immunoreactivity accounting for phosphorylated tau (*P = 0.03 by an unpaired two-tailed t-test). Tg, transgenic.