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Figure 15 | Journal of Neuroinflammation

Figure 15

From: Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models

Figure 15

Quantitation of astrocytosis in the cortex of TgSwDI mice. Reactive astrocytosis was analyzed semiquantitatively on a scale of 0 to 4. Representative brain sections of both (A) vehicle control and (B) pBri-treated Tg mice immunostained with GFAP from the cortex. (C) Bar graph of astrocyte semiquantitative analysis for the cortex of vehicle control and pBri-vaccinated mice. On average there was a 51% reduction in the areas occupied by GFAP immunoreactivity accounting for astrocytosis (*P = 0.015 by an unpaired two-tailed t-test). GFAP, glial fibrillary acidic protein; Tg, transgenic.

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