Skip to main content
Figure 17 | Journal of Neuroinflammation

Figure 17

From: Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models

Figure 17

Quantitation of microgliosis in the cortex of 3xTg mice. Microglial burden was analyzed semiquantitatively on a scale of 0 to 4. Representative brain sections of both (A) vehicle control and (B) pBri-treated Tg mice immunostained with CD45 from the cortex. (C) Bar graph of microglia semiquantitative analysis for the cortex of vehicle control and pBri-vaccinated mice. On average there was a 91% reduction in the areas occupied by CD45 immunoreactivity accounting for microgliosis (***P = 0.0001 by an unpaired two-tailed t-test). GFAP, glial fibrillary acidic protein; Tg, transgenic.

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094