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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models

Figure 2

Antibody titers in plasma reactive against purified human paired helical filaments (PHF) at Tf and characterization of the PHF preparation. Titers for the TgSwDI and 3xTg mice were determined against human purified PHF at Tf for both IgM and IgG and were compared to vehicle-inoculated Tg controls. Shown are the titers for TgSwDI IgM (A), TgSwDI IgG (B), 3xTg IgM (C) and 3xTg IgG (D). These differences in titer are statistically significant by two-way unpaired t-tests (P = 0.0038, P = 0.0037, P = 0.0057 and P = 0.04, respectively). (E) Western blot of the human PHF sample used to seed the ELISA plates in (A) to (D). (F) Electron micrograph of the human PHF sample used, revealing the expected paired helical filaments. OD, optical density; Tg, transgenic.

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