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Figure 20 | Journal of Neuroinflammation

Figure 20

From: Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models

Figure 20

Quantitation of microglial burden in the hippocampus of 3xTg mice. Microglial burden was analyzed semiquantitatively on a scale of 0 to 4. Representative brain sections of both (A) vehicle control and (B) pBri-treated Tg mice immunostained with CD45 from the hippocampus. (C) Bar graph of microglia semiquantitative analysis for the hippocampus of vehicle control and pBri-vaccinated mice. On average there was a 63% reduction in the areas occupied by CD45 immunoreactivity accounting for microgliosis (**P = 0.0035 by an unpaired two-tailed t-test). Tg, transgenic.

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Journal of Neuroinflammation

ISSN: 1742-2094