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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Immunomodulation targeting of both Aβ and tau pathological conformers ameliorates Alzheimer’s disease pathology in TgSwDI and 3xTg mouse models

Figure 4

Quantitation of Aβ burden in the hippocampus of TgSwDI mice. Representative brain sections of both (A) vehicle control and (B) pBri-treated Tg mice immunostained with anti-Aβ antibodies 4G8 and 6E10 from the hippocampus. (C) Bar graph of amyloid burden calculated using stereology for the hippocampus of vehicle control and pBri-vaccinated TgSwDI mice. On average there was a 42% reduction in the areas occupied by 4G8/6E10 immunoreactivity (*P = 0.039 by an unpaired two-tailed t-test). Tg, transgenic.

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Journal of Neuroinflammation

ISSN: 1742-2094