Figure 5

Quantitation of Aβ burden in the cortex of TgSwDI mice. Representative brain sections of both (A) vehicle control and (B) pBri-treated Tg mice immunostained with anti-Aβ antibodies 4G8 and 6E10 from the cortex. (C) Bar graph of amyloid burden calculated using stereology for the cortex of vehicle control and pBri-vaccinated TgSwDI mice. On average there was a 70% reduction in the areas occupied by 4G8/6E10 immunoreactivity accounting for precipitated amyloid (***P = 0.0004 by an unpaired two-tailed t-test). Tg, transgenic.