Inflammatory gene expression in Rasmussen’s encephalitis (RE).
A) CD3ϵ, HLA-DR, TNFα and GFAP mRNA median RFC of white matter and cortical samples from RE patients (n = 3) compared to non-RE (n = 6) controls revealed significantly increased immune gene transcript levels in RE white matter samples compared to non-RE specimens. B) IL-1β, NLRP1, NLRP3, casp1, IL-18, and C) ASC mRNA RFC of white matter and cortical samples from RE patients compared to non-RE revealed an increase in expression of all genes in RE white matter as well as cortex for some genes. Student’s t-test, *P >0.05. RE, Rasmussen’s encephalitis; RFC, relative fold change.