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Figure 10 | Journal of Neuroinflammation

Figure 10

From: Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor

Figure 10

The proinflammatory cytokine IL-1β is upregulated acutely after traumatic axonal injury with hypoxia (TAI + Hx), and its production is suppressed acutely by erythropoietin (EPO). (A) IL-1β levels were elevated acutely above sham levels at 2 h after TAI, with an increase approaching significance to sham in both TAI and TAI + EPO groups. No statistical differences were found between TAI and TAI + EPO groups at any time point examined (2, 24, or 48 h). (B) TAI + Hx rats had a striking significant increase in IL-1β levels acutely at 2 h when compared with sham. When TAI + Hx rats were treated with a single dose of EPO 1 h after injury, IL-1β levels were suppressed and remained at sham values, in contrast to saline-treated TAI + Hx rats. Data expressed as mean ± SEM, n = 4/group. *P <0.05; 2-way ANOVA with post-hoc Bonferroni test.

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Journal of Neuroinflammation

ISSN: 1742-2094