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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor

Figure 8

The erythropoietin receptor (EpoR) is expressed predominantly on neurons. Representative images of immunofluorescent double labeling employed to determine co-localisation between EpoR (middle panel) and neurons (A; NeuN), damaged axons (B; NF-200) in the brainstem at 1d, macrophages/microglia (C; CD68), and astrocytes (D; GFAP) in the corpus callosum at 7 d. EpoR co-localised mostly with NeuN, having a sporadic overlap with CD68. No colocalisation was found for EpoR and NF-200 or GFAP. (E) Demonstrates a lack of positive staining in negative control slides. Scale bar = 100 μm.

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