Figure 8From: Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor The erythropoietin receptor (EpoR) is expressed predominantly on neurons. Representative images of immunofluorescent double labeling employed to determine co-localisation between EpoR (middle panel) and neurons (A; NeuN), damaged axons (B; NF-200) in the brainstem at 1d, macrophages/microglia (C; CD68), and astrocytes (D; GFAP) in the corpus callosum at 7 d. EpoR co-localised mostly with NeuN, having a sporadic overlap with CD68. No colocalisation was found for EpoR and NF-200 or GFAP. (E) Demonstrates a lack of positive staining in negative control slides. Scale bar = 100 μm.Back to article page