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Figure 9 | Journal of Neuroinflammation

Figure 9

From: Erythropoietin improves motor and cognitive deficit, axonal pathology, and neuroinflammation in a combined model of diffuse traumatic brain injury and hypoxia, in association with upregulation of the erythropoietin receptor

Figure 9

Accumulation of CD68-positive macrophages and microglia is reduced by erythropoietin (EPO) treatment after traumatic axonal injury with hypoxia (TAI + Hx). In the corpus callosum CD68-positive (+ive) staining was classified on the basis of macrophage or microglial appearance, with the number of each counted separately. (A) The ratio of macrophages to microglia demonstrated a shift between 7 and 14 d in TAI + EPO rats, with an early predominance of macrophages, followed by a more abundant accumulation of microglia at 14 d. (B) The ratio of macrophages to microglia was similar at both 7 and 14 days in both TAI + Hx and TAI + Hx + EPO rats. Data expressed as mean ± SEM, n = 6/group.

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