Changes of inflammatory mediators in the injured brains as determined by ELISA in control group (n = 6), subarachnoid hemorrhage (SAH) group (n = 6), SAH + vehicle group (n = 6), and SAH + tamoxifen group (n = 6). SAH could induce the significantly increased concentrations of IL-1β, TNF-α and IL-6 in the rat brain after SAH. In SAH + tamoxifen group, the cortical concentrations of IL-1β, TNF-α, and IL-6 were markedly downregulated following SAH. *P <0.05 and **P <0.01 between control animals versus SAH animals; #P <0.05 and ##P <0.01 between SAH + vehicle animals versus SAH + tamoxifen animals; n.s. P >0.05 between SAH animals versus SAH + vehicle animals.