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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Tamoxifen as an effective neuroprotectant against early brain injury and learning deficits induced by subarachnoid hemorrhage: possible involvement of inflammatory signaling

Figure 7

Representative images of the Morris water maze (MWM) trials of the rats of four groups. Bottom: Spatial learning and memory in the MWM. Escape latency and swimming distance over 16 trials (A, C) and averaged for each day (B, D) over days 2 to 5. The percent improvement in escape latency from the previous training day was significantly lower on day five in the subarachnoid hemorrhage (SAH) group as compared to controls (E, *P <0.01). The tamoxifen group was higher on day four than the vehicle group (E, #P <0.01). The control group exhibited significantly longer time except on day 6 as compared to the SAH group on the working memory task (matching-to-place task) by the time saved in latency for finding the platform on the second (test) trial compared to the first (sample) trial (F, *P <0.01). There was no significant difference between the tamoxifen group and the vehicle group (values are means ± SD, n = 10 per group).

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Journal of Neuroinflammation

ISSN: 1742-2094