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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia

Figure 8

Schematic representation of the role of A 2A R in the control of BDNF release and microglial proliferation selectively in activated microglia. (A) Constitutive release of BDNF is under the control of PKC (non-treated cells). (B) In the presence of an inflammatory trigger, LPS, the increase in A2AR density (1) and the subsequent downstream activation of AC-cAMP-PKA (2) prevails over PKC actions, inducing an increase in BDNF release (3), which increases microglial proliferation (4). AC, adenylyl cyclase; cAMP, cyclic AMP; IN, intracellular compartment; PKA, protein kinase A; PKC, protein kinase C.

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