Effects of GSK0660 and GW9662 treatment on palmitoylethanolamide-induced improvement of locomotion after spinal cord injury. The degree of motor disturbance was assessed every day until 10 days after spinal cord injury (SCI) by Basso Mouse Scale (BMS) criteria. Palmitoylethanolamide (PEA)treatment (10 mg/kg) caused a significant increase in Basso, Beattie and Bresnahan (BBB) locomotor rating scale. Pretreatment with GSK0660 (A) or GW9662 (B) abolished PEA-induced improvement of locomotion after SCI. Overall BBB scores of injured PPAR-αKO mice (B) were lower than injured WT mice (A). PEA-treated PPAR-αKO mice did not show a recovery of locomotor function (B).