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Figure 12 | Journal of Neuroinflammation

Figure 12

From: Toll-like receptor 4 mediates microglial activation and production of inflammatory mediators in neonatal rat brain following hypoxia: role of TLR4 in hypoxic microglia

Figure 12

Toll-like receptor 4 (TLR4) inhibition suppressed the increased inducible nitric oxide synthase (iNOS) expression on microglia in the corpus callosum and cerebellum in neonatal rats after hypoxic treatment. Confocal images showing the expression of iNOS expression in lectin-labeled (green) microglia in the corpus callosum (A) and cerebellum (B) of control, hypoxia and hypoxia + CLI-095 rats at 3 h after the hypoxic exposure. (A) iNOS expression was barely detected on microglia of control rats; however, it was markedly enhanced in hypoxic rats. The expression was decreased on microglia of hypoxia + CLI-095 rats compared with the hypoxic rats. (B) A similar phenomenon was observed in microglia in the cerebellum. Scale bars in A and B = 50 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094