CD88 immunoreactivity is also abundantly present in neurofibrillary tangles of AD cases. Immunostaining using two antibodies against different CD88 epitopes: Novus carboxy terminal (A, B) and Abcam amino terminal (C) in hippocampus of VD (A) and AD cases (B, C). Arrow and arrowhead show neuropil threads and tangles respectively. Scale bar: 50 um. AD, Alzheimer’s disease; VD, vascular dementia.