Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response

Table 2 Effects of RA on ischemia-reperfused diabetic rats: a dose–response study

Group	Survival (# rats)	Neurological scores (median/range)	Blood glucose (mM)	Infarct volume (%)	Brain water content (%)
Control	10/10	—	5.2 ± 0.6	—	76.8 ± 0.3
Diabetic	10/10	—	19.1 ± 2.3	—	77.0 ± 0.4
Vehicle	8/10	4/2^#	19.8 ± 2.5	28.4 ± 5.3^#	79.5 ± 0.4^#
RA 12.5	9/10	3/3	19.6 ± 2.6	24.5 ± 5.4	79.3 ± 0.4
RA 25	9/10	3/4^*	19.5 ± 2.4	21.8 ± 5.7^*	79.0 ± 0.5^*
RA 50	10/10	2/3^**	20.1 ± 2.7	19.7 ± 5.2^**	78.9 ± 0.3^**
RA 100	10/10	2/3^**	19.7 ± 2.6	16.5 ± 4.4^**	78.7 ± 0.4^**
RA 200	10/10	2/3^**	19.6 ± 2.8	15.5 ± 3.2^**	78.6 ± 0.5^**

Data are means ± SD, with n = 10 for each group. RA at doses ranging from 12.5 to 200 mg/kg, was administered intravenously 30 minutes after cerebral I/R. RA indicates rosmarinic acid, Control indicates non-diabetic rats. ^# P <0.01 vs. Diabetic group; ^* P <0.05, ^** P <0.01 vs Vehicle-treated group. Cerebral infarct volume and brain water content between groups were compared using one-way ANOVA followed by Dunnett's test. Neurological scores between groups were compared using a nonparametric test.

ISSN: 1742-2094