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Table 2 Effects of RA on ischemia-reperfused diabetic rats: a doseresponse study

From: Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response

Group Survival (# rats) Neurological scores (median/range) Blood glucose (mM) Infarct volume (%) Brain water content (%)
Control 10/10 5.2 ± 0.6 76.8 ± 0.3
Diabetic 10/10 19.1 ± 2.3 77.0 ± 0.4
Vehicle 8/10 4/2# 19.8 ± 2.5 28.4 ± 5.3# 79.5 ± 0.4#
RA 12.5 9/10 3/3 19.6 ± 2.6 24.5 ± 5.4 79.3 ± 0.4
RA 25 9/10 3/4* 19.5 ± 2.4 21.8 ± 5.7* 79.0 ± 0.5*
RA 50 10/10 2/3** 20.1 ± 2.7 19.7 ± 5.2** 78.9 ± 0.3**
RA 100 10/10 2/3** 19.7 ± 2.6 16.5 ± 4.4** 78.7 ± 0.4**
RA 200 10/10 2/3** 19.6 ± 2.8 15.5 ± 3.2** 78.6 ± 0.5**
  1. Data are means ± SD, with n = 10 for each group. RA at doses ranging from 12.5 to 200 mg/kg, was administered intravenously 30 minutes after cerebral I/R. RA indicates rosmarinic acid, Control indicates non-diabetic rats. # P <0.01 vs. Diabetic group; * P <0.05, ** P <0.01 vs Vehicle-treated group. Cerebral infarct volume and brain water content between groups were compared using one-way ANOVA followed by Dunnett's test. Neurological scores between groups were compared using a nonparametric test.