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Table 3 Effects of RA on survival, neurological scores, infarct volume and brain water content in ischemia-reperfused diabetic rats: a therapeutic time-window study

From: Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response

Group Survival (# rats) Neurological scores (median/range) Infarct volume (%) Brain water content (%)
Diabetic   10/10 77.0 ± 0.5
Vehicle-treated   8/10 4/2 27.7 ± 4.7 79.6 ± 0.4#
  1 h 10/10 2/3** 19.0 ± 4.4** 78.8 ± 0.4**
RA 3 h 10/10 2/3* 21.5 ± 4.5** 79.0 ± 0.4*
5 h 9/10 3/4* 22.8 ± 2.8* 79.1 ± 0.4*
7 h 9/10 3/4 24.1 ± 4.0 79.3 ± 0.4
  1. Data are means ± SD, with n = 10 for each group. RA was administered at a dose of 50 mg/kg at 1 h, 3 h, 5 h and 7 h after cerebral I/R. RA indicates rosmarinic acid. Data are means ± SD. # P <0.01 vs. diabetic animals; * P <0.05, ** P <0.01 vs vehicle-treated group. Cerebral infarct volumes of different groups were compared using one-way ANOVA followed by Dunnett's test. Neurological deficit scores between groups were compared using a nonparametric test.