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Table 3 Effects of RA on survival, neurological scores, infarct volume and brain water content in ischemia-reperfused diabetic rats: a therapeutic time-window study

From: Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response

Group

Survival (# rats)

Neurological scores (median/range)

Infarct volume (%)

Brain water content (%)

Diabetic

 

10/10

—

—

77.0 ± 0.5

Vehicle-treated

 

8/10

4/2

27.7 ± 4.7

79.6 ± 0.4#

 

1 h

10/10

2/3**

19.0 ± 4.4**

78.8 ± 0.4**

RA

3 h

10/10

2/3*

21.5 ± 4.5**

79.0 ± 0.4*

5 h

9/10

3/4*

22.8 ± 2.8*

79.1 ± 0.4*

7 h

9/10

3/4

24.1 ± 4.0

79.3 ± 0.4

  1. Data are means ± SD, with n = 10 for each group. RA was administered at a dose of 50 mg/kg at 1 h, 3 h, 5 h and 7 h after cerebral I/R. RA indicates rosmarinic acid. Data are means ± SD. # P <0.01 vs. diabetic animals; * P <0.05, ** P <0.01 vs vehicle-treated group. Cerebral infarct volumes of different groups were compared using one-way ANOVA followed by Dunnett's test. Neurological deficit scores between groups were compared using a nonparametric test.
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Journal of Neuroinflammation

ISSN: 1742-2094