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Table 4 Effects of RA on survival, neurological scores, blood glucose and infarct volume in ischemia-reperfused rats: a long-term study

From: Rosmarinic acid protects against experimental diabetes with cerebral ischemia: relation to inflammation response

Group

Time (days)

Survival (# rats)

Neurological scores (median/range)

Blood glucose (mM)

Infarct volume (%)

Vehicle

3

12/15

4/3

20.3 ± 3.1

30.3 ± 5.1

7

12/15

3/4

20.5 ± 3.2

14

12/15

3/4

20.7 ± 3.4

RA50

3

14/15

2/4**

20.5 ± 2.9

 

7

14/15

2/4*

20.4 ± 3.1

 

14

14/15

2/4*

20.7 ± 3.2

13.9 ± 4.7**

  1. RA was administered at a dose of 50 mg/kg as a single intravenous bolus injection 30 minutes after cerebral I/R. RA indicates rosmarinic acid. Data are means ± SD, each group contains 15 rats. * P <0.05, ** P <0.01 vs vehicle-treated group. Cerebral infarct volumes of different groups were compared using one-way ANOVA followed by Dunnett's test. Neurological deficit scores between groups were compared using a nonparametric test.
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Journal of Neuroinflammation

ISSN: 1742-2094