Cystometric evaluation of bladder function before and after the development of a neurogenic bladder. (A-B) Representative traces of the cystometrograms recorded in a freely moving transient receptor potential vanilloid 1 knockout (TRPV1−/−) mouse before (A) and after (B) the induction of colonic inflammation. Arrows point to non-micturition contractions. (C) Comparison of the duration of intermicturition interval (IMI) in wild-type (WT) and genetically modified mice. (D) Analysis of bladder capacity (BC) before and after 2,4,6-trinitrobenzene sulfonic acid (TNBS) treatments. (E) Changes in the voided volume induced by experimental colitis. BP, bladder pressure. *P ≤0.05 to respective vehicle group, #P ≤0.05 to WT group.