Contractility of the detrusor muscle isolated from WT and TRPV1 KO mice. (A) Representative raw tracers of the detrusor contractile responses to electric field stimulation (EFS) in wild-type (WT) and transient receptor potential vanilloid 1 knockout (TRPV1−/−) mice. (B) Normalized contractile response of isolated detrusor smooth muscle (DSM) strips in response to electric field stimulation (EFS, 32 Hz). (C) Representative raw tracers of the detrusor muscle responses to KCl stimulation in WT and TRPV1−/− mice. (D) Changes in the peak amplitude of the detrusor muscle contractions upon stimulation with 125 mM of potassium chloride (KCl). All results are presented as mean ± SEM. Star symbol marks the statistical significance between the groups.