Status epilepticus (SE) after administration of lipopolysaccharide (LPS) with or without anti-inflammatory drugs. Mean (± SEM) of both time to onset (open bar) and total duration (open + filled bar) after pilocarpine treatment following a prior injection of LPS or LPS + combination of anti-inflammatory drugs. The latency to pilocarpine-induced seizure onset in combination treatment of COX-2 inhibitor plus rIL-1ra with LPS was significantly delayed as compared to those given vehicle (*P <0.01). There were no significant changes in total duration of SE among groups. CAY, COX-2 inhibitor; MINO, minocycline; rIL-1ra = recombinant interleukin-1 receptor antagonist; VEHS, vehicles.