Skip to main content
Figure 11 | Journal of Neuroinflammation

Figure 11

From: Transmigration of polymorphnuclear neutrophils and monocytes through the human blood-cerebrospinal fluid barrier after bacterial infection in vitro

Figure 11

Cytokines and chemokines released during monocyte transmigration. The supernatants of transwell filters were analyzed after monocyte TM experiments for different cytokines/chemokines (pg/ml) with cytokine bead array (CBA) after stimulation of human choroid plexus papilloma cells (HIBCPP) with strain α14, strain MC58, strain MC58ΔsiaD or TNFα. IL10, IL1α, IL1β, IL-6 and TNFα display a group of cytokines mainly secreted after monocytes have migrated through infected HIBCPPs (A-E). GRO (CXCL1,2,3,) and IL-8 were already secreted by HIBCPP when stimulated with bacteria alone (F-G). Macrophage inflammatory protein (MIP)-1α and MIP-1β were released after bacterial stimulation of monocytes (H-I). Data shown are mean ± SD of two independent experiments and two filters per condition analyzed in duplicate. * P <0.05; ** P <0.01; *** P <0.001 compared to stimulated HIBCPP with and without monocytes. # P <0.05; ## P <0.01; ### P <0.001 compared to TNFα-stimulated cells.

Back to article page