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Figure 6 | Journal of Neuroinflammation

Figure 6

From: TNF-α promotes cerebral pericyte remodeling in vitro, via a switch from α1 to α2 integrins

Figure 6

Pericyte α2 integrin is induced during cerebrovascular remodeling in vivo . Pericyte expression of (A) α1 and (B) α2 integrins (both Alexa Fluor-488, green) was analyzed by dual immunofluorescence (IF) with the pericyte marker NG2 (Cy3, red) in frozen brain sections taken from mice with acute experimental autoimmune encephalomyelitis (EAE) or control mice. Scale bar = 50 μm. (C) Quantification of this data. Each point represents the mean ± SEM of three different experiments. Note that α1 integrin strongly co-localized to NG2-positive pericytes, both in control and acute EAE tissue, whereas α2 integrin expression was undetectable on cerebral vessels in control tissue, but showed strong induction on pericytes in the acute EAE brain. P<0.001.

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