Figure 3
From: Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
Expression of markers for M1 and M2 phenotype in white matter of control brain. Sections of white matter of control brain were stained using immunohistochemistry. Proteolipid protein (PLP) staining shows normal abundant myelin (A) Human leukocyte antigen-DR (HLA-DR) and CD68 staining reveals positive microglia (B,C). M1 markers, including CD40, and CD86 were expressed on microglia (D,E). Antibodies directed against CD64 and CD32 clearly decorated microglia (F,G), whereas MR and CD163 were expressed by perivascular macrophages (H-I).