Figure 4
From: Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
Expression of M1 and M2 markers in active multiple sclerosis (MS) lesions. Images were taken from the center of active demyelinating lesion. Proteolipid protein (PLP) staining shows widespread demyelination and PLP-laden macrophages (insert) (A). Intense labeling of human leukocyte antigen-DR (HLA-DR) and CD68 positive cells was observed in the center and rim of the lesion. CD68, CD40, CD86, CD64 and CD32 were markedly expressed by macrophages throughout the lesion area (D-G). Mannose receptor (MR) and CD163 were highly expressed by foamy macrophages (H,I).