Figure 6
From: Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status
Expression of markers for M1 and M2 phenotype in a chronic active lesion. (A) Proteolipid protein (PLP) staining of a chronic active lesion shows massive demyelination and PLP positive macrophages in the insert. Human leukocyte antigen-DR (HLA-DR) expression was profound at the rim of chronic active lesions (B). CD68, CD40, CD86, CD64 and CD32 are all clearly expressed by microglia at the rim of the lesion. Images of macrophage markers were taken at the rim of the lesion (C-G). Mannose receptor (MR)-positive and CD163-positive macrophages were predominantly observed in the perivascular space (H-I).