Macrophages in inflammatory multiple sclerosis lesions have an intermediate activation status

Table 3 Marker expression in multiple sclerosis (MS) lesions

Macrophage	Antigen	Control	NAWM	Active lesion	Chronic active lesion
Pan marker	CD68	+	+	+++	+++
M1	CD40	+	+	+++	+++
	CD86	+	+	++	+++
	CD64	++	++	+++	+++
	CD32	++	++	++	++
M2	Mannose receptor	-	-	+++	-
	CD163	-	-	+++	-

NAWM, normal appearing white matter; ‘-‘ indicates no positive cells; ‘+’ indicates few macrophages stain positive or the expression level is low; ‘++’ indicates that the majority (>50%) of the macrophages stain positive; ‘+++’ indicates that all macrophages stain positive.

ISSN: 1742-2094