Figure 2

Schematic overview of the vimentin and GFAP staining after central fluid percussion injury (cFPI) in mice at post-injury day 1,3 and 7. (A) The immunoreactivity for vimentin was increased in the cortex, the subcortical white matter, the fimbria of hippocampus and the dentate gyrus of hippocampus in addition to the external and internal capsule (arrow), especially at 3 days post-injury. Note the absence of increased vimentin staining in the thalamus; (B) Sham-injured animals showed some background staining of GFAP, which increased after cFPI. The increased GFAP staining was observed in the cortex, the subcortical white matter, the fimbria of hippocampus and the dentate gyrus of the hippocampus and in the thalamus (arrow). Note the absence of increased GFAP staining in the internal capsule; (C) Vimentin and GFAP staining in three different brain regions after cFPI or sham injury; (D) The corpus callosum; (E) the dentate gyrus of the hippocampus and (F) the internal capsule. PID: Post-injury day.