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Figure 8 | Journal of Neuroinflammation

Figure 8

From: Traumatic axonal injury in the mouse is accompanied by a dynamic inflammatory response, astroglial reactivity and complex behavioral changes

Figure 8

The principal component analysis (PCA) from the first MCSF test at 2 days post-injury. To test the hypothesis that the mouse cFPI model induces unique behavioral deficits compared to a focal traumatic brain injury (TBI) model, we extracted historical data [28] obtained under an identical set-up and by the same investigator. (A) PCA score plot showing a comparison between mice subjected to the controlled cortical impact (CCI, producing a focal TBI) model and the cFPI model, producing wide-spread traumatic axonal injury. The behavioral patterns of the two TBI models are markedly different; (B) PCA loading plot illustrating the MCSF variables that were included in the analysis. Variables located further away from the origin are most important for the model. CCI: Controlled cortical impact, n = 11 (from [28]); cFPI: Central fluid percussion injury, n= 15; CTRCI: Central circle; Dur: Duration; D/V: Duration per visit; Frq: Frequency; Lat: Latency; SLOPE E: Slope entrance; TOT ACTIVITY: Total activity in arena; TOTCORR: Total corridor entries.

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