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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Brucella abortus induces TNF-α-dependent astroglial MMP-9 secretion through mitogen-activated protein kinases

Figure 3

HKBA and L-Omp19 induce p38 and Erk1/2 phosphorylation in astrocytes. Astrocytes were stimulated with HKBA (A, C), L-Omp19 or U-Omp19 (1,000 ng/ml) (B, D). MAPK phosphorylation was determined by Western blot. Total and phosphorylated Erk1/2 (A, B, upper panels). Total and phosphorylated p38 (C, D, upper panels). PMA was used as a positive control. Densitometric analysis of results from three independent experiments as performed in (A-D), lower panels. *P < 0.1, **P < 0.01, ***P < 0.001 for comparisons with non-stimulated (NS) astrocytes. The data shown are from a representative experiment of three performed.

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