Figure 8

Patients with neurobrucellosis display MMP-9 activity in their CSF. CSF and serum samples were obtained from non-infected controls (C1 and C2), patients who had neurobrucellosis (NB1, NB2 and NB3), a patient who had brucellosis without neurological involvement (Br) and CSF samples from patients who had meningitis caused by infectious agents other than Brucella spp. (Staphylococcus aureus, SaM, and Streptococcus spp., SsM). Antibodies against Brucella cytoplasmic proteins (a-CP) and LPS (a-LPS) were detected in CSF and serum samples. Culture to detect Brucella spp. presence was assayed in CSF (A). MMP-9 in CSF samples was detected by zymography (B). Values in Table A correspond to antibody titers against CP and LPS. ND: non-determined.