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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Human marrow stromal cells reduce microglial activation to protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis

Figure 1

Human marrow stromal cell transplantation delayed disease progression and prolonged survival in SOD1 mice. Cumulative probability of disease onset (A) and survival (B) for Cu/Zn superoxide dismutase 1 (SOD1) mice beginning at 8 weeks of age treated with intrathecal injection of human marrow stromal cells (hMSCs), relative to PBS treatment. Survival and onset of SOD1 mice were significantly improved by hMSC treatment (*P <0.01). (C) Effect of hMSC treatment on motor performance in G93A SOD1 transgenic mice from 8 weeks of age. There was a significantly improved motor performance in G93A mice treated with hMSC injection from 15 to 17 weeks of age (*P <0.01). Values are mean ± standard error of the mean.

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Journal of Neuroinflammation

ISSN: 1742-2094