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Figure 3 | Journal of Neuroinflammation

Figure 3

From: Human marrow stromal cells reduce microglial activation to protect motor neurons in a transgenic mouse model of amyotrophic lateral sclerosis

Figure 3

Inhibition of microglial activation by human marrow stromal cell treatment in SOD1 transgenic mice. Activation of microglia were detected by CD11b immunoreactivity in the spinal cord ventral gray of wild-type mice (A), PBS-treated transgenic mice (B), and human marrow stromal cell (hMSC)-treated transgenic mice (C) at the age of 15 weeks at 400× magnification. Higher-magnification images are shown in the insert for resting microglia (A) and activated microglia (B). Quantitative cell counts of CD11b-positive microglia in the ventral gray of mice at 11 weeks of age (D) and 15 weeks of age (E). Intrathecally injected hMSCs significantly suppressed microglial activation in Cu/Zn superoxide dismutase 1 (SOD1) transgenic mice (*P <0.01 versus PBS alone).

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