ICE KO mice were protected from depression-like behaviors following ICV administration of LPS compared to WT mice. (a) Time of immobility in the FST was determined 24 h after treatment. WT mice given LPS had greater time spent immobile compared to control WT mice, while immobility time in LPS-treated ICE KO mice was not different from control mice. (b) WT, but not ICE KO, mice displayed decreased preference for sucrose during the 24 to 48 h period following LPS injection. Data represent averages ± SEM. n = 9 to 12 mice per group, *P <0.05 comparing bracketed treatment groups.