Figure 1

Experimental controls. (A) Western-blot analysis of bradykinin receptor 1 (B₁R) pre-immune (PI) and anti-serum on kidney extracts from two wild-type (WT; 1,2) and two B₁R knockout (KO; 3,4) mice. The anti-B₁R antibody recognized a single band at the expected molecular weight (37 kDa), which was absent in B₁R KO mice or in the presence of pre-immune serum. Dynein was used as standard. (B) Transgenic amyloid precursor protein (APP) mice featured increased expression of APP in both brain and pial vessels extracts, as measured by western blot. APP protein levels were not affected by vehicle (−) or treatment (+).