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Figure 9 | Journal of Neuroinflammation

Figure 9

From: Cognitive and cerebrovascular improvements following kinin B1 receptor blockade in Alzheimer’s disease mice

Figure 9

Effects of SSR240612 treatment on cerebral kinin receptors and on endothelial NOS and vascular B 2 R protein levels. (A,B) Single bands were detected at 37 and 135 kDa by anti-B1R and anti-eNOS antibodies, respectively, whereas anti-B2R antibodies decorated a characteristic doublet around 42 kDa. No change in cortical B1R and B2R (A) or in hippocampal B2R (B) protein levels was observed, but B1R were upregulated in the hippocampus of APP mice (B), with no effect of treatment. (C) In pial vessels, protein levels of endothelial NOS (eNOS) and B2R were normalized by B1R blockade. Blots images illustrate the 5 weeks of treatment. *P <0.05; **P <0.01, Two-way ANOVA followed by Newman-Keuls post hoc test. Blots images illustrate the 5 weeks of treatment. N = 5 to 6/group. APP, amyloid precursor protein; B2R, bradykinin receptor 2.

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