Acute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration

Table 2 IL-1β administration-induced changes in concentrations of pro-inflammatory and anti-inflammatory cytokines in the hippocampus

	Acute saline administration	Acute IL-1 administration	Subacute saline administration	Subacute IL-1 administration
IL-1β	1579.3 ± 187.2	2016.3 ± 245.2	1523.53 ± 248.52	4072.07 ± 496.04^b
TNF-α	214.63 ± 25.82	1079.74 ± 124.18^a	188.03 ± 26.65	1268.01 ± 154.76^b
IL-10	91.92 + 9.53	127.72 + 12.64^a	98.76 + 6.82	72.35 + 5.47^a

Cytokine concentrations were expressed as mean ± SEM in pg/mg protein; ^a P <0.05 and ^b P <0.01 versus matched controls (n = 8).

ISSN: 1742-2094