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Table 3 A summary of changes in glial cell markers, neurotrophins and cytokine concentrations in rat hippocampus after acute and subacute IL-1 administrations

From: Acute and subacute IL-1β administrations differentially modulate neuroimmune and neurotrophic systems: possible implications for neuroprotection and neurodegeneration

  Acute IL-1 Subacute IL-1
  qPCR Western or kit qPCR Western or kit
CD11 NS + + ++
GFAP NS + NS _
NGF + + NS NS
BDNF + + _ _
TrK A NS _ NS +
TrK B + NS _ _
p75 _ _ + +
APP NS NS + +
IL-1β   NS   +
TNF-α   +   ++
IL-10   +   _
  1. As compared to acute and subacute IL-1 administrations with control groups, +, significantly up-regulated or increased; -, significantly down-regulated or decreased and NS, not significantly changed. GFAP, glial fibrillary acidic protein; NGF, nerve growth factor; BDNF, brain-derived neurotrophic factor; TrK, tyrosine kinase; APP, amyloid precursor protein.