Application of recombinant IL-1β impairs neurological outcome after spinal cord compression injury. (A) Locomotion analysis using the Basso Mouse Scale (BMS) showed significant worsening of neurological outcome after spinal cord compression injury (SCI) and local administration of recombinant IL-1β (rIL-1β) in Gelfoam directly after SCI. The rIL-1β-treated mice scored more than 1 point of the BMS less than control mice (scoring respectively 4.5 and 6), most probably reflecting lack of coordination and consistent plantar stepping in the treated mice. (B) The paw positioning subscore differed significantly between the two groups, while the stepping subscore did not. *P <0.05, two-way analysis of variance.