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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia

Figure 1

Increased quantity of CD207-positive LCs in the epidermis and subepidermal plexus were detected in db/db mice during the period of mechanical allodynia. Representative double immunofluorescent images of CD207 (green: A,C,D,F) and CD68 (red: B,C,E,F) immunohistochemistry on hind foot pads from db/+ (A,B,C) and db/db mice (D,E,F) at 8 weeks of age. Increased numbers of CD207-positive cells in the epidermal Langerhans cells (ELCs, arrows) and subepidermal Langerhans cells (SLCs, arrowheads) were detected in db/db mice (compare A and D). In contrast, trace CD68 immunoreactivity was observed in ELCs of db/db mice (E, arrows). SLCs were mostly positive for CD68 (B,E, arrowheads). Bar = 50 μm, n = 8. ELC, epidermal Langerhans cell; Epi, epidermis; LC, Langerhans cell; SLC, subepidermal Langerhans cell.

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