Figure 6
From: Neurogenic factor-induced Langerhans cell activation in diabetic mice with mechanical allodynia
Increased TNF-α expression in the subepidermal plexus of db/db mice. Representative images of TNF-α/CD68 double immunohistochemistry of hind foot pads from db/+ (A,B,C) and db/db (D,E,F) mice at 8 weeks of age. Increased TNF-α immunoreactivity was detected in the subepidermal plexus (A,D, arrows), along with increased quantities of subepidermal CD68-positive cells (B,E, arrowheads). Bar = 50 μm, n = 8. Epi, epidermis.