Figure 3

Astrogliosis in the adult Grid2 ^Lc/+ cerebellum. Representative electron microscopy views of the molecular layer (A) and of the internal granular layer (B). In the molecular layer, a few surviving parallel fibers (pf) are wrapped in abnormally abundant, superimposed astrocytic processes (asterisk); G, glial cell soma with electrolucent cytoplasm; n, nucleus. In the internal granular layer, abundant astrocytic processes are stacked around a cerebellar glomerulus made of a mossy fiber-like terminal (mf) forming asymmetric synapses (arrowheads) on a few granule cell dendrites (gc), which receive inputs from Golgi neuron terminals (go) at symmetric synapses (arrows). Bar: 500 nm.