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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Toll-like receptor stimulation increases phagocytosis of Cryptococcus neoformans by microglial cells

Figure 2

Phagocytic rates of C. neoformans in stimulated wild-type and MyD88-deficient microglial cells after 120 minutes of phagocytosis. Microglia were either unstimulated or stimulated with Pam3CSK4 0.1 μg/ml, polyinosine-polycytidylic acid (poly (I:C)) 30 μg/ml, lipopolysaccharide (LPS) 0.01 μg/ml or CpG 1 μg/ml for 24 h. Phagocytosed cryptococci (colony-forming units (CFU)/well) were converted into percentage, and the median number of intracellular cryptococci from wild-type cells was considered to be 100% (n ≥12 wells/group from three independent experiments). Data are given as medians with interquartile ranges. Data were analyzed by Kruskal-Wallis test followed by Dunn’s multiple comparison test to correct for repeated testing; * P <0.05, ** P <0.01; n.s., not significant; wt, wild-type.

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