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Figure 13 | Journal of Neuroinflammation

Figure 13

From: Primary blast injury-induced lesions in the retina of adult rats

Figure 13

Distribution of TUNEL and caspase-3 immunoreactive cells in the retina of sham rats (A, B), BH 2 w (C, D) and BL 2 w rats (E, F). Blast exposure, especially BH (C, E), increases the incidence of apoptotic cells (black arrows) in the ONL compared to sham animals (A). Scale bar=50 μm (A, C, E). Similarly, blast exposure, especially BH (D, F), results in an increase in caspase-3 immunofluorescence (red) in the neurons in or between the outer and inner granular cell bipolar layers compared to sham animals (A). Scale bar=20 μm (B, D, F). (G) Bar graphs show increase in apoptotic cells at 72 h and 2 weeks after BH and BL exposure when compared with that of the sham rats. The frequency of apoptotic cells is significantly increased in the retina at 2 weeks after BH exposure when compared with that of 72 h after BH exposure and 72 h and 2 w after BL exposure, respectively (mean±SD) (* P <0.05; **P <0.01).

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