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Figure 4 | Journal of Neuroinflammation

Figure 4

From: Dual effects of noradrenaline on astroglial production of chemokines and pro-inflammatory mediators

Figure 4

NA effects on different chemokines. (A) Astrocytes were incubated with control media or NA 10 μM for 1, 2, 6 or 24 hours. RNA was isolated and mRNA levels of CCL6, CCL7, CCL12 and CXCL16 were determined by RT-PCR. Data are expressed as percentage of control values (set to 100%). *P <0.05 versus control; **P <0.01 versus control; ***P <0.001 versus control. Data are means ± SE of n = 8 replicates per group. (B) Astrocytes were incubated with control media (white columns), LPS 0.1 μg/ml (black columns) or LPS and NA 10 μM (gray columns) for 1, 2, 6 or 24 hours. RNA was isolated and mRNA levels of CCL6, CCL7, CCL12 and CXCL16 were determined by RT-PCR. Data are expressed as percentage of control values (set to 100%). *P <0.05 versus control; **P <0.01 versus control; ***P <0.001 versus control; Φ P <0.05 versus LPS; ΦΦ P <0.01 versus LPS; ΦΦΦ P <0.001 versus LPS. Data are means ± SE of n = 8 replicates per group. C, control; CCL6, chemokine (C-C motif) ligand 6; CCL7, chemokine (C-C motif) ligand 7; CCL12, chemokine (C-C motif) ligand 12; CXCL16, chemokine (C-X-C motif) ligand 16; LPS, lipopolysaccharide; NA, noradrenaline; RT-PCR; reverse transcription polymerase chain reaction; SE, standard error.

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