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Figure 2 | Journal of Neuroinflammation

Figure 2

From: DAP12 and CD11b contribute to the microglial-induced death of dopaminergic neurons in vitro but not in vivo in the MPTP mouse model of Parkinson’s disease

Figure 2

Microglial expression of Dap12 is induced in the mouse ventral mesencephalon following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. (A) Real-time quantitative PCR analysis of Dat, Cd11b and Dap12 transcripts in the ventral mesencephalon before (NaCl) and after MPTP intoxication at the indicated times. * P <0.05 compared to NaCl-treated controls; Holm-Sidak post hoc analysis. RQV, relative quantity value; d, days. (B) Double immunofluorescent staining for CD11b (red) and DAP12 (green) on mesencephalic tissue sections from control or MPTP-injected mice 2 days after toxin exposure. The arrows indicate hypertrophied and double-labeled microglial cells at the level of the SN pars compacta. Scale bar: 30 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094