Figure 4

Mouse deficiency in either DAP12 or CD11b does not mitigate 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced nigrostriatal pathway injury in vivo . Quantification of striatal tyrosine hydroxylase (TH) immunoreactivity (optical density) and TH⁺ dopaminergic neurons in the SN pars compacta from DAP12^KI or CD11b KO and their wild-type (WT) littermates at day 21 (A and B; subchronic regimen of intoxication) or 7 (C and D; acute regimen of intoxication) after the last injection of MPTP (black bars) or saline solution (white bars). Irrespective of the mode of intoxication (subchronic or acute), a significant loss of both striatal dopaminergic fibers and nigral DN were observed in all MPTP-treated groups compared to their respective saline controls. No significant differences were found between genotypes. ^* P <0.001 compared to saline-treated mice, Holm-Sidak post hoc analysis.