Figure 1

Vasospasm time course in subarachnoid hemorrhage model. A. Hematoxylin and Eosin (H&E) stain of coronal section through middle cerebral artery (MCA) in sham from post-operative day (POD) 7. Scale Bars are all: 10 μm. B. H&E of MCA stain after subarachnoid hemorrhage (SAH) induction on POD 7. C. Shows a diagram of the coronal section where MCA dimensions were measured for vasospasm analysis. D. Lumen radius/wall thickness was measured to determine the degree of vasospasm. Student’s t-test was done for each POD and significant differences between sham and SAH were noted for POD 3, 7, 10 and 15 with P-values of <0.001, <0.04, <0.001 and <0.01, respectively. Error bars are standard deviations and N = 4 per group.